Livia Schiavinato EberlinAssistant Professor
Department of Chemistryliviase@utexas.edu
The University of Texas at Austin
Department of Chemistry, College of Natural Sciences
105 East 24th Street
Austin, TX 78712
Stanford University, 2012 - 2015 Postdoctoral Fellow (Chemistry)
Purdue University, 2008 - 2012 Ph.D. in Chemistry (Analytical Chemistry)
State University of Campinas, 2004 – 2007 B.S. in Chemistry
Research in the Eberlin group focuses on applying novel mass spectrometry imaging technology to health related research. Our main goal is to develop innovative ambient mass spectrometry techniques and methodologies in combination with statistical and molecular biology tools to investigate the molecular information from a variety of biological samples. In particular, we are interested in using ambient mass spectrometry in creative ways to address critical problems in cancer research. Using ambient mass spectrometry, we investigate the metabolic profiles of tissues and other clinical specimens. We correlate the metabolic information obtained with molecular and clinical data to better understand and diagnose disease. In basic cancer research, we are interested in studying tumor tissue behavior and chemically characterizing metabolic signatures of human cancers. We also pursue improvements in MS instrumentation in order to translate the tools developed in the laboratory to the clinic for in situ, real-time disease diagnosis. Our interdisciplinary research is carried out in collaboration with biologists, oncologists, surgeons, pathologists and statisticians to develop powerful approaches that can be used in real life scenarios such as in clinical practice. For more information on our exciting research projects, please visit our group website.
1. L.S. Eberlin, M. Gabay, A.C. Fan, R. Tibshirani, D. Felsher, and R.N. Zare, “Alteration of the Lipid Profile in Lymphomas Induced by MYC Overexpression”, Proceedings of the National Academy of Sciences of the U.S.A., 2014, 111, 10450-10455.
2. L.S. Eberlin, J.V. Mulcahy, A. Tzabazis, J. Zhang, M. Logan, H.J. Roberts, G.K. Lee, D.C. Yeomans, J. Du Bois, and R.N. Zare, “Visualizing Dermal Permeation of Sodium Channel Modulators by Mass Spectrometric Imaging”, Journal of the American Chemical Society, 2014, 136, 6401-6405.
3. S. Santagata, L.S. Eberlin, I. Norton, D. Calligaris, D.R. Feldman, J.L. Ide, X. Liu, J.S. Wiley, M.L. Vestal, S.H. Ramkissoon, D.A. Orringer, K.K. Gill, I.F. Dunn, D. Dias-Santagata, K.L. Ligon, F.A. Jolesz, A.J. Golby, R.G. Cooks, and N.Y.R. Agar, “Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery”, Proceedings of the National Academy of Sciences of the U.S.A., 2014, 111, 11121-11126.
4. L.S. Eberlin, I. Norton, D. Orringer, I. F. Dunn, X. Liu, J.L. Ide, A.K. Jarmusch, K.L. Ligon, F.A. Jolesz, A.J. Golby, S. Santagata, N.Y. R. Agar and R.G. Cooks, “Ambient Mass Spectrometry for the Intraoperative Molecular Diagnosis of Human Brain Tumors”, Proceedings of the National Academy of Sciences of the U. S.A., 2013, 110, 1611-1616.
5. L.S. Eberlin, I. Norton, A.L. Dill, A.J. Golby, K.L. Ligon, S. Santagata, R.G. Cooks and N.Y.R. Agar, "Classifying Human Brain Tumors by Lipid Imaging with Mass Spectrometry", Cancer Research, 2012, 72, 645-654.
6. L.S. Eberlin, C.R. Ferreira, A.L. Dill, L.Cheng and R.G. Cooks, "Non-Destructive, Histologically Compatible Tissue Imaging by Desorption Electrospray Ionization Mass Spectrometry", ChemBioChem, 2011, 12, 2129 -2132.
7. L.S. Eberlin, D.R. Ifa, C.Wu, R.G. Cooks, "Three-Dimensional Visualization of Mouse Brain by Lipid Analysis Using Ambient Ionization Mass Spectrometry", Angewandte Chemie International Edition, 2010, 49, 873-876.
2015 K99/R00 NIH/NCI Pathway to Independence Award
2015 Named among “Forbes’ 30 under 30” list in Healthcare
2014 L’Oréal USA For Women in Science Fellowship
2014 American Chemical Society Nobel Laureate Signature Award for Graduate Education in Chemistry
2012 M.G. Mellon Award in Analytical Chemistry, Purdue University, IN, USA