Que, Emily

Emily Que

Assistant Professor
Department of Chemistry



emilyque@cm.utexas.edu

Phone: 512-471-4490

Office Location
WEL 4.314

Postal Address
The University of Texas at Austin
Department of Chemistry, College of Natural Sciences
105 East 24th Street
Stop A5300
Austin, TX 78712

BS, University of Minnesota, 2004

PhD, University of California Berkeley, 2009

Postdoctoral Studies, Northwestern University, 2009-present

Bioinorganic Chemistry and Chemical Biology

Research in the Que lab is centered in bioinorganic chemistry and chemical biology. Our interdisciplinary research bridges the fields of coordination chemistry, synthetic chemistry, and chemical biology to gain a molecular understanding of biological processes including those in cancer and reproductive biology. We seek to develop small molecule imaging tools based on both organic and metal complex platforms that can be used for visualizing cellular processes in single cells, tissues, and whole organisms using a number of imaging modalities including fluorescence microscopy and magnetic resonance imaging (MRI). In addition, chemical tools and methods will be developed to help us gain a quantitative understanding of how metal ions function in cells during key cellular transitions.

Marvin, R. G.; Wolford, J. L.; Kidd, M. J.; Murphy, S.; Ward, J.; Que, E. L.; Mayer, M. L.; Penner-Hahn, J. E.; Jaldar, K.; O’Halloran, T. V. “Fluxes in ‘Free’ and Total Zinc are Essential for Progression of Intraerythrocytic Stages of Plasmodium falciparum,” Chem. Biol. 2012, 19, 731-741.

Que, E. L.; New, E. J.; Chang, C. J. “A Cell-Permeable Gadolinium Contrast Agent for Magnetic Resonance Imaging of Copper in a Menkes Disease Model,” Chem. Sci. 2012, 3, 1829-1834.

Que, E. L.; Chang, C. J. “Responsive Magnetic Resonance Imaging Contrast Agents as Chemical Sensors for Metals in Biology and Medicine,” Chem. Soc. Rev. 2010, 39, 51-60.

Que, E. L.; Gianolio, E.; Baker, S. L.; Aime, S.; Chang, C.J. “A Copper-Activated Magnetic Resonance Imaging Contrast Agent with Improved Turn-On Relaxivity Response and Anion Compatibility,” Dalton Trans. 2010, 39, 469-476.

Que, E. L.; Gianolio, E.; Baker, S. L.; Wong, A. P.; Aime, S.; Chang, C.J. “Copper Responsive Magnetic Resonance Imaging Contrast Agents,” J. Am. Chem. Soc. 2009, 131, 8527-8536.

Que, E. L.; Domaille, D. W.; Chang, C. J. "Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging," Chem. Rev. 2008, 108, 1517-1549.

Domaille, D. W.; Que, E. L.; Chang, C. J. "Synthetic Fluorescent Sensors for Studying the Cell Biology of Metals," Nat. Chem. Biol. 2008, 4, 168-175.

 Que, E. L.; Chang, C. J. "A Smart Magnetic Resonance Contrast Agent for Selective Copper Sensing," J. Am. Chem. Soc. 2006, 128, 15942-15943.

ACS Division of Inorganic Chemistry Young Investigator Award, 2010