Carlos R BaizAssistant Professor
Department of Chemistrycbaiz@cm.utexas.edu
The University of Texas at Austin
Department of Chemistry, College of Natural Sciences
105 East 24th Street
Austin, TX 78712
B.S. Michigan Technological University, 2002-2005
Ph.D. University of Michigan, 2006-2011
Postdoctoral Fellow, Massachusetts Institute of Technology, 2011-2013
Postdoctoral Fellow, University of Chicago, 2013-2015
Biophysical Chemistry of Lipids and Membrane Proteins
Research in the Baiz group focuses on describing the molecular mechanisms that determine the structure and dynamics of membrane-associated peptides and proteins. We investigate the mechanisms of protein folding, self-assembly, and function with particular interest in understanding the role of heterogeneous environments in lipid membranes. Secondary structure, folding mechanisms, and kinetics are the result of a highly-specific thermodynamic balance between hydrophobic contacts, electrostatics, and solvent-exposure, and for membrane proteins, the environment significantly increases the diversity and complexity of these interactions.
We address these challenging topics by developing new tools based on time-resolved infrared spectroscopy and microscopy. More specifically, we design new applications of two-dimensional infrared spectroscopy, a technique that measures global protein structure, backbone flexibility, and solvent exposure with sub-picosecond time resolution. Experiments are supported by quantum-mechanical models of vibrational spectroscopy combined with extensive structure-based computer simulations.
Please visit our group’s website to learn more about our exciting research projects.
Carlos R. Baiz, and Andrei Tokmakoff “Structural Disorder of Folded Proteins: Isotope-Edited 2D IR Spectroscopy and Markov State Modeling” Biophys J. 108, 7, 1747-1757 (2015)
Carlos R. Baiz, Denise Schach, and Andrei Tokmakoff, “Ultrafast 2D IR microscopy” Optics Express, 22, 18724 (2014)
Carlos R. Baiz, Yu-Shan Lin, Chunte Sam Peng, Kyle A. Beauchamp, Vincent A. Voelz, Vijay S. Pande ,and Andrei Tokmakoff "A Molecular Interpretation of 2D IR Protein Folding Experiments with Markov State Models", Biophysical Journal, 106, 1359 (2014)
Carlos R. Baiz, Chunte S. Peng, Michael E. Reppert, Kevin C. Jones, and Andrei Tokmakoff, “Coherent two-dimensional infrared spectroscopy: Quantitative analysis of protein secondary structure in solution”, Analyst, 137, 1793-1799 (2012)
Carlos R. Baiz and Kevin J. Kubarych, “Ultrafast Transient Vibrational Stark Spectroscopy: Exploring Excited-State Charge-Transfer by Measuring the Solvent Response”, J. Amer. Chem. Soc (Comm), 132 (37), 12784-12785 (2010)
NIH Ruth L. Kirschstein National Research Service Award, 2012-2014
Rackham Predoctoral Fellowship, 2010-2011